Jhoanne Bautista, MD, PhD

Resident Physician
Surgery
+1 415 502-1259

Jhoanne (aka Joey) was born in the Philippines but grew up in New York.  She did her undergrad work at Barnard College, went on to MIT to study inorganic chemistry, but eventually switched gears to pursue MD/PhD in immunology at WashU School of Medicine.  She then moved to UCSF for residency in general surgery, with plans to pursue a clinical fellowship in abdominal transplantation. 

As a graduate student, she worked in the laboratory of Chyi-Song Hsieh MD PhD where she studied the role of TCR signaling in the development of regulatory T cells.  Her current research interest in the Anderson lab centers around the use of bioinformatics to characterize rare cell types (like extrathymic Aire-expressing cells or eTACs) and to map the development of various antigen-presenting cells that might be relevant to the induction of self-tolerance.

Publications: 

Single-cell multiomics defines tolerogenic extrathymic Aire-expressing cells with unique homology to thymic epithelium.

The Journal of Immunology

Jiaxi Wang, Caleb A Lareau, Jhoanne L Bautista, Im Hong Sun, Alexander R Gupta, James M Gardner

Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium.

Science immunology

Wang J, Lareau CA, Bautista JL, Gupta AR, Sandor K, Germino J, Yin Y, Arvedson MP, Reeder GC, Cramer NT, Xie F, Ntranos V, Satpathy AT, Anderson MS, Gardner JM

Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla.

Nature communications

Bautista JL, Cramer NT, Miller CN, Chavez J, Berrios DI, Byrnes LE, Germino J, Ntranos V, Sneddon JB, Burt TD, Gardner JM, Ye CJ, Anderson MS, Parent AV

Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma.

The Journal of clinical investigation

Moore PC, Cortez JT, Chamberlain CE, Alba D, Berger AC, Quandt Z, Chan A, Cheng MH, Bautista JL, Peng J, German MS, Anderson M, Oakes SA

Aire deficiency during early pregnancy leads to maternal T cell imbalance and embryo loss.

The Journal of Immunology

Eva Mae Gillis-Buck, James M. Gardner, Jhoanne L. Bautista, Mark S. Anderson, Adrian Erlebacher, Tippi C. MacKenzie

Autoimmune regulator gene supports maternal-fetal immune tolerance during early pregnancy.

The Journal of Immunology

Eva Mae Gillis-Buck, Jhoanne L. Bautista, Mark S. Anderson, Tippi C. MacKenzie

Responsiveness to IL-2 characterizes a stable Foxp3+ subset in mice (148.16).

The Journal of Immunology

Jhoanne Bautista, Susan Gilfillan, Marco Colonna, Chyi-Song Hsieh

Thymic and peripheral differentiation of regulatory T cells.

Advances in immunology

Lee HM, Bautista JL, Hsieh CS

Sliding set-points of immune responses for therapy of autoimmunity.

The Journal of experimental medicine

Hsieh CS, Bautista JL

Absence of P-selectin in recipients of allogeneic bone marrow transplantation ameliorates experimental graft-versus-host disease.

Journal of immunology (Baltimore, Md. : 1950)

Lu SX, Holland AM, Na IK, Terwey TH, Alpdogan O, Bautista JL, Smith OM, Suh D, King C, Kochman A, Hubbard VM, Rao UK, Yim N, Liu C, Laga AC, Murphy G, Jenq RR, Zakrzewski JL, Penack O, Dykstra L, Bampoe K, Perez L, Furie B, Furie B, van den Brink MR

Intraclonal competition limits the fate determination of regulatory T cells in the thymus.

Nature immunology

Bautista JL, Lio CW, Lathrop SK, Forbush K, Liang Y, Luo J, Rudensky AY, Hsieh CS

An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells.

The Journal of experimental medicine

Graham DB, Stephenson LM, Lam SK, Brim K, Lee HM, Bautista J, Gilfillan S, Akilesh S, Fujikawa K, Swat W

Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice.

The Journal of clinical investigation

Graham DB, Robertson CM, Bautista J, Mascarenhas F, Diacovo MJ, Montgrain V, Lam SK, Cremasco V, Dunne WM, Faccio R, Coopersmith CM, Swat W