Michael Waterfield, MD, PhD

Asst Professor In Residence
Diabetes Center
+1 415 353-7337

Mike grew up in Baltimore, MD and attended Bowdoin College. In 2005, he graduated from Penn State College of Medicine where he received an MD/PhD in Medicine and Cellular & Molecular Biology. He then moved to San Francisco to start a pediatrics residency at UCSF and to be part of the Molecular Medicine Program. After finishing his residency in 2008, he started a pediatric rheumatology fellowship and joined the Anderson Lab as a Postdoctoral Fellow in August 2009. In his spare time, he enjoys biking, running, skiing, hiking, movies, and watching all Baltimore sports teams (especially the Ravens).


Aire in Autoimmunity.

Annual review of immunology

Miller CN, Waterfield MR, Gardner JM, Anderson MS

Ikaros is a principal regulator of Aire+ mTEC homeostasis, thymic mimetic cell diversity, and central tolerance.

Science immunology

Sin JH, Sucharov J, Kashyap S, Wang Y, Proekt I, Liu X, Parent AV, Gupta A, Kastner P, Chan S, Gardner JM, Ntranos V, Miller CN, Anderson MS, Schjerven H, Waterfield MR

ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8+ T Cell Effector and Memory Responses.

Journal of immunology (Baltimore, Md. : 1950)

Sin JH, Kashyap S, Acenas D, Cortez JT, Lee J, Marson A, Matloubian M, Waterfield MR

The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses.

The Journal of experimental medicine

Sin JH, Zuckerman C, Cortez JT, Eckalbar WL, Erle DJ, Anderson MS, Waterfield MR

Analysis of pulmonary features and treatment approaches in the COPA syndrome.

ERJ open research

Tsui JL, Estrada OA, Deng Z, Wang KM, Law CS, Elicker BM, Jones KD, Dell SD, Gudmundsson G, Hansdottir S, Helfgott SM, Volpi S, Gattorno M, Waterfield MR, Chan AY, Chung SA, Ley B, Shum AK

Identification of a novel cis-regulatory element essential for immune tolerance.

The Journal of experimental medicine

LaFlam TN, Seumois G, Miller CN, Lwin W, Fasano KJ, Waterfield M, Proekt I, Vijayanand P, Anderson MS

GILT-mediated processing of a self and melanoma antigen in thymic epithelial cells promotes deletion and regulatory T cells (APP3P.113).

The Journal of Immunology

Matthew Rausch, Todd Metzger, Michael Waterfield, Jessica Cortez, Mark Anderson, Karen Hastings

COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis.

Nature genetics

Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, Anderson MS, Liu D, Tang LF, Nicholas SK, Nahmod K, Makedonas G, Canter DL, Kwok PY, Hicks J, Jones KD, Penney S, Jhangiani SN, Rosenblum MD, Dell SD, Waterfield MR, Papa FR, Muzny DM, Zaitlen N, Leal SM, Gonzaga-Jauregui C

The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.

Nature immunology

Waterfield M, Khan IS, Cortez JT, Fan U, Metzger T, Greer A, Fasano K, Martinez-Llordella M, Pollack JL, Erle DJ, Su M, Anderson MS

Clues to immune tolerance: the monogenic autoimmune syndromes.

Annals of the New York Academy of Sciences

Waterfield M, Anderson MS